Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Mespilus germanica leaves flavonoids improve passive avoidance memory and apoptosis in a rat model of amyloid-β neurotoxicity
Introduction: Alzheimer’s disease (AD) is a common progressive, neurodegenerative disorder with no preventive or curative therapy until now. Use of natural products as an important source of neuroprotective flavonoids against AD has been considered recently. In this study, the effect of Mespilus germanica leaves (MGL) flavonoids treatment on memory dysfunction and apoptosis in the amyloid beta ...
متن کاملMitochondrial Ferritin Deletion Exacerbates β-Amyloid-Induced Neurotoxicity in Mice
Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein which protects mitochondria from iron-induced oxidative damage. Our previous studies indicate that FtMt attenuates β-amyloid- and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. To explore the protective effects of FtMt on β-amyloid-induced memory impairment and neuronal apoptosis and the mechanisms involved, 10-mon...
متن کاملNeuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity
Alzheimer's disease (AD) is known to be caused by the accumulation of amyloid-β peptide (Aβ). The accumulation of Aβ has been shown to cause learning and memory impairment in rats, and it has been shown that hydrogen sulfide donors, such as sodium hydrosulfide (NaHS) can attenuate these effects. However, the underlying mechanisms have not yet been fully eludicated. This study was designed to in...
متن کاملNeurotoxicity of amyloid β-protein: synaptic and network dysfunction.
Evidence for an ever-expanding variety of molecular mediators of amyloid β-protein neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers and related signaling cascades, cytoskeletal proteins, inflammatory mediators, etc.) has led to the notion that the binding of hydrophobic Aβ assemblies to cellular membranes triggers multiple effects affecting diverse pathways...
متن کاملSelective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicity.
Recent studies have emphasized the functional role of the P300/CBP-associated factor (PCAF) enzyme in resistance to β-amyloid (Aβ)-mediated neurotoxicity; however, the underlying mechanisms through which PCAF regulates inflammation and neurotoxicity have not yet been elucidated. In this study, we used computer-based molecular docking simulations to perform structure-based artificial screening f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2003.08.005